Rapid blood-testing technology reduces time between sample and analysis

Lancaster academics are developing blood-testing technology that promises to improve healthcare treatments for cancer patients, post-operative care and monitor the health of babies in the womb is being developed. A portable bedside blood diagnostics device is the focus of a collaborative research project.

The project involves Lancaster-based company eBiogen, clinicians from Morecambe Bay NHS Foundation Trust, and academics from Lancaster University’s Chemistry Department and Faculty of Health and Medicine.

The new small-scale technology, called ‘EBio-LacSens’, would rapidly measure blood characteristics to monitor for sepsis or toxins. It would be a good indicator of the success of treatments following operations and it could ensure the early detection of sepsis in chemotherapy patients. In addition it could help evaluate the status of fetuses.

The device does this by taking pinprick samples of blood and providing rapid chemical analysis – in less than a minute. This quick processing of samples, when compared to the traditional process where samples that have to be sent for analysis at hospital laboratories (a process that can take hours), enables medical staff to quickly adjust treatments in response to the improved data.

Michael Mumford, from eBiogen, said: “This project passed its feasibility stage and it is now progressing well in its prototype stage with encouraging results. We are starting the human blood testing soon before proceeding to market. Lancaster University has enabled us to develop a rich and supportive expert network.”

By bringing blood diagnostics closer to the patient there are additional benefits of reduced risk of contamination and cost savings.

Dr Mukesh Kumar, the project Research Fellow, said, “Although the existing point-of-care testing kits have resolved a few conventional problems, they have not had a great impact in most clinical testing. The new technology would circumvent many current problems through miniaturization, enabling an economical, portable analyzer to be used ‘by the bedside’. The prospect of being able to significantly reduce the time between taking a sample and the delivery of the analysis is exciting and rewarding.”

The point-of-care market has been estimated (by a Yole Development study in the US) at $38bn (£28.7bn) in 2017. This $38bn represents 16% of the whole In‐Vitro‐Diagnostic (IVD) market.

Professor Peter Fielden, Head of Chemistry at Lancaster University, said: “Working with eBiogen has given us a great opportunity to develop our academic ideas through technology transfer into real devices that will have significant impact in healthcare.”

An additional benefit to the technology is that it uses very small samples of blood plasma – a few microliters (pinprick droplets) as opposed to several milliliters (a full vial) as required by current testing procedures. This is a significant improvement when dealing with young children and patients with poor blood vessels.

The researchers are also exploring additional future potential applications for the technology. These could include environmental monitoring and food security. Dr David Telford, Consultant Microbiologist at Morecambe Bay NHS Foundation Trust said: “A unique feature of this new project is the close links and networks developing between academics and clinical end-users at all stages of product development from concept to marketing. This ensures that our products are useful in the modern health care environment.”

The £50,000 project was part-funded with £25,000 from the Engineering and Physical Sciences Research Council through its Impact Acceleration Account. This funding was matched by eBiogen and has been used to pay for research time, prototype development and sample testing. The collaboration has also received support from the Lancaster Health Hub.

The Impact Acceleration Account is £900,000 funding from the Engineering & Physical Sciences Research Council to finance a range of activities designed to foster greater collaboration with industry, and bridge the gap between the lab and the marketplace.

More information: Lancaster University